Antimicrobial antagonists against food pathogens; a bacteriocin perspective
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Paula M. O’Connor, R. Paul Ross, Colin Hill, Paul D. Cotter. Antimicrobial antagonists against food pathogens; a bacteriocin perspective. Current Opinion in Food Science, (2015), volume 2, pages 51-57. doi:10.1016/j.cofs.2015.01.004Abstract
Efforts are continuing to find novel bacteriocins with enhanced specificity and potency. Traditional plating techniques are still being used for bacteriocin screening studies, however, the availability of ever more bacterial genome sequences and the use of in silico gene mining tools have revealed novel bacteriocin gene clusters that would otherwise have been overlooked. Furthermore, synthetic biology and bioengineering-based approaches are allowing scientists to harness existing and novel bacteriocin gene clusters through expression in different hosts and by enhancing functionalities. The same principles apply to bacteriocin producing probiotic cultures and their application to control pathogens in the gut. We can expect that the recent developments on bacteriocins from Lactic Acid Bacteria (LAB) described here will contribute greatly to increased commercialisation of bacteriocins in food systems.Funder
Science Foundation IrelandGrant Number
12/RC/2273ae974a485f413a2113503eed53cd6c53
http://dx.doi.org/10.1016/j.cofs.2015.01.004