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dc.contributor.authorEarley, Bernadette*
dc.contributor.authorBuckham-Sporer, Kelly*
dc.contributor.authorGupta, Sandeep*
dc.contributor.authorPang, Wanyong*
dc.contributor.authorTing, Simon*
dc.date.accessioned2012-08-14T15:39:42Z
dc.date.available2012-08-14T15:39:42Z
dc.date.issued2010-08-04
dc.identifier.citationBiologic response of animals to husbandry stress with implications for biomedical models.B. Earley, K. Buckham-Sporer, S. Gupta et al. Open Access Animal Physiology, (2010), 2(1), 25-42.DOI: http://dx.doi.org/10.2147/OAAPS9354en_GB
dc.identifier.issn1179-2779
dc.identifier.urihttp://hdl.handle.net/11019/80
dc.descriptionPeer-revieweden_GB
dc.description.abstractThe quality of life of animals is defined by a range of parameters including health, physiology, and behavior. Stress is defined as any damaging strain, force, or agent which stimulates a physiologic defense reaction and is capable under certain circumstances of producing pathologic lesions. Disruption to normal homeostasis can impinge on other biologic processes such as metabolism, cardiovascular activity, immune function, and behavior. In general, chronic stress is considered to have a greater potential impact on animal health and welfare than acute stress, because the animals are exposed and reacting to the stressor(s) for longer periods, thereby causing prolonged disruption to homeostasis and related biologic processes. Impaired coping responses may trigger specific alterations in behavior, organ damage, reduced performance, increased susceptibility to disease, and subfertility. At a molecular level, immune function is mediated by the release of cytokines, nonantibody messenger molecules from a variety of cells of the immune system and from other cells, such as endothelial cells. Biochemical alterations in immune function are, in part, induced by plasma hormone concentration changes elicited by a stressor subsequent to activation of the sympathetic nervous system, the sympathetic adrenomedullary axis, and the hypothalamo–pituitary–adrenocortical axis.en_GB
dc.language.isoenen_GB
dc.publisherDove Pressen_GB
dc.relation.ispartofseriesOpen Access Animal Physiology;Vol. 2
dc.subjectstressen_GB
dc.subjectinflammationen_GB
dc.subjectanimal modelsen_GB
dc.subjectphysiologyen_GB
dc.subjectimmunologyen_GB
dc.subjectbehaviouren_GB
dc.titleBiologic response of animals to husbandry stress with implications for biomedical modelsen_GB
dc.typeArticleen_GB
dc.identifier.rmisGEAB-0204-5477
dc.identifier.doihttp://dx.doi.org/10.2147/OAAPS9354
refterms.dateFOA2018-01-12T07:31:11Z


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