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    A Bioengineered Nisin Derivative to Control Biofilms of Staphylococcus pseudintermedius

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    Author
    Field, Des
    Gaudin, Noemie
    Lyons, Francy
    O'Connor, Paula M.
    Cotter, Paul D.
    Hill, Colin
    Ross, R Paul
    Keyword
    Biofilms
    Antibiotics
    Antimicrobials
    Antibiotic resistance
    Date
    19/03/2015
    
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    URI
    http://hdl.handle.net/11019/819
    Citation
    Field D, Gaudin N, Lyons F, O'Connor PM, Cotter PD, Hill C, et al. (2015) A Bioengineered Nisin Derivative to Control Biofilms of Staphylococcus pseudintermedius. PLoS ONE 10(3): e0119684. doi:10.1371/journal.pone.0119684
    Abstract
    Antibiotic resistance and the shortage of novel antimicrobials are among the biggest challenges facing society. One of the major factors contributing to resistance is the use of frontline clinical antibiotics in veterinary practice. In order to properly manage dwindling antibiotic resources, we must identify antimicrobials that are specifically targeted to veterinary applications. Nisin is a member of the lantibiotic family of antimicrobial peptides that exhibit potent antibacterial activity against many gram-positive bacteria, including human and animal pathogens such as Staphylococcus, Bacillus, Listeria, and Clostridium. Although not currently used in human medicine, nisin is already employed commercially as an anti-mastitis product in the veterinary field. Recently we have used bioengineering strategies to enhance the activity of nisin against several high profile targets, including multi-drug resistant clinical pathogens such as methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant enterococci (VRE) and also against staphylococci and streptococci associated with bovine mastitis. However, newly emerging pathogens such as methicillin resistant Staphylococcus pseudintermedius (MRSP) pose a significant threat in terms of veterinary health and as a reservoir for antibiotic resistance determinants. In this study we created a nisin derivative with enhanced antimicrobial activity against S. pseudintermedius. In addition, the novel nisin derivative exhibits an enhanced ability to impair biofilm formation and to reduce the density of established biofilms. The activities of this peptide represent a significant improvement over that of the wild-type nisin peptide and merit further investigation with a view to their use to treat S. pseudintermedius infections.
    Funder
    Science Foundation Ireland
    Grant Number
    10/IN.1/B3027
    ae974a485f413a2113503eed53cd6c53
    http://dx.doi.org/10.1371/journal.pone.0119684
    Scopus Count
    Collections
    Food Biosciences
    Food Biosciences
    Food Biosciences
    Food Biosciences

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