• Current trends in sample preparation for growth promoter and veterinary drug residue analysis

      Kinsella, Brian; O'Mahony, John; Malone, Edward; Moloney, Mary; Cantwell, Helen; Furey, A.; Danaher, Martin; Department of Agriculture, Food and the Marine, Ireland; 06RDTAFRC479; 07FHRITAFRC5 (Elsevier, 09/09/2009)
      A comprehensive review is presented on the current trends in sample preparation for isolation of veterinary drugs and growth promotors from foods. The objective of the review is to firstly give an overview of the sample preparation techniques that are applied in field. The review will focus on new techniques and technologies, which improve efficiency and coverage of residues. The underlying theme to the paper is the developments that have been made in multi-residue methods and particularly multi-class methods for residues of licensed animal health products, which have been developed in the last couple of years. The role of multi-class methods is discussed and how they can be accommodated in future residue surveillance.
    • Residue analyses and exposure assessment of the Irish population to nitrofuran metabolites from different food commodities in 2009–2010

      Radovnikovic, Anita; Conroy, Emma-Rose; Gibney, Mike; O'Mahony, John; Danaher, Martin; Department of Agriculture, Food and the Marine, Ireland; Health Research Board; 07FHRIAFRC5 (Taylor & Francis, 16/09/2013)
      An exposure assessment to nitrofuran residues was performed for three human populations (adults, teenagers and children), based on residue analyses of foods of animal origin (liver, honey, eggs and aquaculture) covering the 2-year period 2009– 2010. The occurrence of nitrofuran metabolites in food on the Irish market was determined for the selected period using the data from Ireland’s National Food Residue Database (NFRD) and from results obtained from the analysis of retail samples (aquaculture and honey). Laboratory analyses of residues were performed by methods validated in accordance with Commission Decision 2002/657/EC regarding performance of the analytical method and interpretation of results. Semicarbazide (SEM) was the contaminant most frequently identified and its content ranged from 0.09 to 1.27 μg kg−1. SEM is currently used as a marker of nitrofuran abuse, but it may also occur from other sources. The presence of nitrofuran metabolite 3-amino-2-oxazolidinone (AOZ) was detected in two aquaculture samples (prawns) at 1.63 and 1.14 μg kg−1, but such a low number of positive cases did not present sufficient data for a full AOZ exposure assessment. Therefore, the evaluation of exposure was focused on SEM-containing food groups only. Exposure assessments were completed using a probabilistic approach that generated 10 iterations. The results of both the upper- and lower-bound exposure assessments demonstrate that SEM exposure for Irish adults, teenagers and children from selected food commodities are well below EFSA-estimated safe levels.