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dc.contributor.authorCronin, Owen
dc.contributor.authorBarton, Wiley
dc.contributor.authorMoran, Carthage
dc.contributor.authorSheehan, Donal
dc.contributor.authorWhiston, Ronan
dc.contributor.authorNugent, Helena
dc.contributor.authorMcCarthy, Yvonne
dc.contributor.authorMolloy, Catherine B
dc.contributor.authorO’Sullivan, Orla
dc.contributor.authorCotter, Paul D.
dc.contributor.authorMolloy, Michael G
dc.contributor.authorShanahan, Fergus
dc.date.accessioned2020-07-03T15:59:10Z
dc.date.available2020-07-03T15:59:10Z
dc.date.issued2019-02-12
dc.identifier.citationCronin, O., Barton, W., Moran, C. et al. Moderate-intensity aerobic and resistance exercise is safe and favorably influences body composition in patients with quiescent Inflammatory Bowel Disease: a randomized controlled cross-over trial. BMC Gastroenterol 19, 29 (2019). https://doi.org/10.1186/s12876-019-0952-xen_US
dc.identifier.urihttp://hdl.handle.net/11019/2154
dc.descriptionpeer-revieweden_US
dc.description.abstractBackground Overweight and metabolic problems now add to the burden of illness in patients with Inflammatory Bowel Disease. We aimed to determine if a program of aerobic and resistance exercise could safely achieve body composition changes in patients with Inflammatory Bowel Disease. Methods A randomized, cross-over trial of eight weeks combined aerobic and resistance training on body composition assessed by Dual Energy X-ray Absorptiometry was performed. Patients in clinical remission and physically inactive with a mean age of 25 ± 6.5 years and Body Mass Index of 28.9 ± 3.8 were recruited from a dedicated Inflammatory Bowel Disease clinic. Serum cytokines were quantified, and microbiota assessed using metagenomic sequencing. Results Improved physical fitness was demonstrated in the exercise group by increases in median estimated VO2max (Baseline: 43.41mls/kg/min; post-intervention: 46.01mls/kg/min; p = 0.03). Improvement in body composition was achieved by the intervention group (n = 13) with a median decrease of 2.1% body fat compared with a non-exercising group (n = 7) (0.1% increase; p = 0.022). Lean tissue mass increased by a median of 1.59 kg and fat mass decreased by a median of 1.52 kg in the exercising group. No patients experienced a deterioration in disease activity scores during the exercise intervention. No clinically significant alterations in the α- and β-diversity of gut microbiota and associated metabolic pathways were evident. Conclusions Moderate-intensity combined aerobic and resistance training is safe in physically unfit patients with quiescent Inflammatory Bowel Disease and can quickly achieve favourable body compositional changes without adverse effects. Trial registration The study was registered at ClinicalTrials.gov; Trial number: NCT02463916 .en_US
dc.language.isoenen_US
dc.relation.ispartofseriesBMC Gastroenterology;
dc.subjectClinical trialsen_US
dc.subjectMicrobiomeen_US
dc.subjectExerciseen_US
dc.subjectBody compositionen_US
dc.titleModerate-intensity aerobic and resistance exercise is safe and favorably influences body composition in patients with quiescent Inflammatory Bowel Disease: a randomized controlled cross-over trialen_US
dc.typeArticleen_US
dc.date.updated2019-02-17T04:17:59Z
dc.language.rfc3066en
dc.rights.holderThe Author(s).
dc.identifier.doihttps://doi.org/10.1186/s12876-019-0952-x
dc.contributor.sponsorIrish Centre for Arthritis Research and Education (ICARE)en_US
dc.contributor.sponsorScience Foundation Irelanden_US
dc.contributor.sponsor13/SIRG/2160en_US
dc.contributor.sponsorGrantNumberSFI/12/RC/2273en_US
dc.contributor.sponsorGrantNumber11/PI/1137en_US
refterms.dateFOA2020-07-03T15:59:11Z


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